If you're thinking in terms of wmv or wma or even possibly rm files then see:
http://www.gnutellaforums.com/showth...threadid=31862
As for others it's highly unlikely at present. However, the hidden extension concept is a possibility. Which is why everybody should be armed with a battery of tools like:
http://www.gnutellaforums.com/showth...threadid=34464