Hi, I had the same problem, all working fine, ran windows update, installed .net v2, did some spyware removal and something broke somewhere.... I tried reinstalling limewire, rebooting etc.. etc.. but was still bust, was just hanging on the initial splashscreen.
Anyway, I fixed it by uninstalling java from control panel and reinstalling from
http://java.com/en/download/index.jsp
.NET v2 knackering java installs by any chance ?? now THATS one for the conspiricy theorists to get excited about :-)
Hope this helps someone else,
Rob