Panda Platinum Internet Security 2005
MS Antispyware Beta 1(Is free if you really look around. Was formerly called Giant antispyware, Before MS bought the rights)
SpywareBlaster (Free) Blocks out many sites connected to malware distribution
Ad-Aware SE PRO (Don't need Pro version. The Free version is almost as good. Pro only has a few more features)

CCleaner (Free) is also a good supplement for keeping your PC in good shape, just don't be too triggerhappy or it might get you in trouble

PeerGuardian2 (Free) for safer P2P sharing

Registry Mechanic for optimizing performance (Could be better featurewise especially cause it isn't free. (the free version is not worth the download)). Need something better. Anyone have a clue as to what program is better. Free or payd for doesb't matter.