This is not sophisticated, and I am not going to surmise or investigate why this worked. Don't care; it worked for me. I have spent two weeks combing these forums and other sources for the answer to why limewire 4.9.something quit working and why a fresh install of 4.10, after a clean deinstallation of 4.9, also would crash on startup. Some say it is java this or that, some say it's the boogie man, and some just rant.

Try this:
1. Take note of your current installation directory. On Windows, the default is C:\Program Files\Limewire; that is what I had.
2. Uninstall whatever version that you have.
3. Download 4.10
4. Install 4.10 TO A DIFFERENT DIRECTORY THAN WHERE THE PREVIOUS INSTALLATION WAS. I had the default, and I had tried to reinstall three times, but I had always just gone with the same directory. So, for whatever reason, it occured to me to name a different directory today when I tried it. I chose C:\Program Files\Limewire_4.10.5. I doubt that it matters; it you have whatever problem I had, then probably any name will do.

Just trying to give a little back. Have a good one.