I wouldn't have a clue. Did you try Java 1.4.2? Did you check the sticky on graphic card issues? Do you have a spyware program that might think LW is harmful so has removed some of its components? Brainstorm I guess. Good luck!
How about your firewalls? Did you configure you system firewall to allow LW full access? Did you enable UPnP on your modem/router?
Using your browser go here:
http://www3.limewire.com:6346/ The page should say 'Your test worked!'. What happens when you go there? If you can't reach it then that's a double-whammy.