Well, I can only tell you how I see it.
Regardless of where I get a file from, how big the file is, what extension it has or what name it bears, I'll scanned it with AVG, Ewido, SpwSweeper and any other means I have just to make sure I'm as save as possible. However, there is no 100% guaranty and no-one can foresee the future and what kind of nasties the bad guys are able to develop.......