Try updating your Java (point 1 below). Make sure to use the offline JRE installer & remove your current version of Java before installing the new one.
Fixes for LimeWire

You could also try deleting LW's preferences folder when LW's closed (points 2 & 3 above).

There are a few more links to mouse problems in the thread below, too. See if they're any help
http://www.gnutellaforums.com/showth...ighlight=mouse