I'm only running Norton, which had LW on its exceptions list and is disabled for now anyway.
I tried ALL the fixes:
I uninstalled my Java, and re-installed JDK 1.6.0 (which includes JRE)
Uninstalled/Re-installed LW again
deleted the .limewire preferences folder
Tried all the compatibility settings (95, 98/ME, NT 4.0 SP5, 2000)
And attempted to run it under Administrator

The only noticeable difference was that some of the compatibility settings didn't show the splash screen. :S

I DID happen to notice that each time LW failed to open, an error log was created in its installation folder as follows:
#
# An unexpected error has been detected by Java Runtime Environment:
#
# EXCEPTION_STACK_OVERFLOW (0xc00000fd) at pc=0x0353a497, pid=3764, tid=2128
#
# Java VM: Java HotSpot(TM) Client VM (1.6.0-b105 mixed mode, sharing)
# Problematic frame:
# C [nvappfilter.dll+0xa497]
#
# If you would like to submit a bug report, please visit:
# http://java.sun.com/webapps/bugreport/crash.jsp
#

--------------- T H R E A D ---------------
bla-bla-bla-bla lots of meaningless numbers that I doubt you want me to post.

Does that get us anywhere?