Delete LW's preferences folder when LW's properly closed. See point 3 here & also point 2 if you've used much older versions of LW in the past (there could be a folder in either location).
Fixes for LimeWire
This will kill all of your settings within options, you'll have to go back through afterwards & reset things.

Have a read of these threads & see if anything helps.

LW Mouse Disabled
mouse buttons not working
Can't click in Limewire

Did you try reinstalling or updating drivers? I don't know much about mouse problems, maybe someone else will be able to help you further.