I have used Limewire for years now and I had problems with it when I first got my XP! I soon figured out it was a Zonelarm problem and fixed that. Sadly now I have Vista I am having problems again .... I have tried all the suggestions here and I know for a fact its not my firewalls, antivirus progs causing it. I can't be bothered going thru this grief every time I get a new OS. So until Limewire consider getting their act together I am going to be using Ares. It connects first time everytime and is way faster.
Sorry Limewire but I have moved on.