I had two Gnucleus s running at the same time for a while, set the ports to different numbers 6346 and 6347 and double clicked on them from within their separate folders from windows explorer
don't know about xolox but it should work if you set the ports
you can run the new opensource network client at the same time I just found it had 75 GB files available so I don't need to run the old one anymore!