All of my downloads (mostly movies) go to D: I later move them to E: so they won't be fragmented (saves a lot of space and makes for quicker burn to DVD). I got really tired of trying to defrag D: after a few movie downloads.

Remember to check your Incomplete folder for olde stuff that you thought you deleted (in LimeWire, under "Library" tab, select "Incomplete" from the left panel). While there, you can also choose to resume downloads you may have forgotten about. Be sure to get rid of any "Preview" files (created if you previewed any downloads).