IMO, There are just to many Variables, to say that one set of settings will work for everyone.
Just play around with Your Settings and see what works Best for You.
I will give you a few suggestions... and I believe these are all right here in the Forums as I don't use LW.
All accessed from Tools > Options
1. Speed... Disable OOB Searching
2. Max Downloads... 5 (my opinion)
3. Upload Slots... 3 (my opinion)
4. Max Upload Slots...5 (my opinion)
5. Go To Advanced > Performance... Disable ALL Three (Up capabilites, DHT, and TLS).
6. Don't Run on System Startup.
Anyone else have any suggestions, feel free to join in.