Make sure you do not port forward any of the same ports as your wife uses. Each application on each computer must be using a different port.

She probably needs to reboot. Sorry, but when changing router settings, it's one of those things .. reboots usually fix it. Hopefully lol

Well .. if you did not set up a static ip address, the problem is, next time you restart your computer or router or the ip changes, the ip will change & you will not be connecting so luckily at a guess with your program.