I am having the same problems with Limewire as described above. It is the ONLY program i am running at the moment shows has these problems, and it is VERY frustrating.
I am not hugely knowledgable in these areas, but pointing the finger at OS X (which i have no problems with except when Limewire is active) is unacceptable.
Is it normal to have such a large slice of memory allocated to the application? (49 MB in my case)
I think its less than appropriate to provide such a flimsy response.