Yes overnet and emule are kings of the hill for big files, no question about that. Ares is a very fast little network, the only drawback is that its network topology (clusters of 10 000 clients) make it difficult to find things that aren't very popular. This program based on gift is also very good. It connects to Gnet, fasttrack (with upload) and openfasttrack.
http://kceasy.sourceforge.net/ It is poisoned for windows users. Recommended.