As the philosophers chant goes...
"Yes, but (maybe) no !" 
But, we need to know about your system and your connection and what p2p client you are using or wish to try.
There are many posts here on this subject and, unfortunately, there is no one 'panacaeic' solution to cover all the possible 'problems' that may need to be overcome...
First thing to try, just before you diligently reply with your essential info,
is to click on the
Port :6346 - Test If It Is 'Blocked'
link in my 'sig' below...