same left mouse button problem
 

so, i downloaded limewire. worked until i shut off computer, then my left mouse button would not work. deleted my limewire program & my java, re-installed them. worked ok until i shut off my computer. same thing again - after deleting & re-installing java & limewire, worked ok. now i have downloaded both java & limewire 5 tirms and no results. opening page comes up, but my left mouse buttton does nothing in limewire - but works EVERYWHERE else. using XP, limewire PRO 4.12.11, J2SE Runtime Environment 5.0 Update 3; a wired mouse with scroller wheel. PLEASE HELP !!!

You could try deleting your prefernce folder and see if that helps...
Fixes for Limewire when LW isn't operating as it should